Geosciences for Elementary Educators: A Course Assessment

Geosciences for Elementary Educators engages future elementary teachers in a hands-on investigation of topics aligned with the third and fifth grade Earth/Space Science and Scientific Inquiry benchmarks of the Oregon Content Standards. The course was designed to develop the content background of elementary teachers within the framework of the science described in the content standards, to provide an opportunity for future teachers to explore the content area in relation to what takes place in the classrooms of elementary schools, and to initiate a community of learners focused on teaching science to elementary students. The course focused on four themes: the classroom teacher as an activity and curriculum developer using diverse resources to keep the content current and alive; the classroom teacher as educator dealing with the diverse backgrounds of students in a developmentally appropriate manner; the classroom teacher as reflective practitioner exploring the links among pedagogy, content, and student learning; and, the classroom teacher as citizen staying current with emerging policy issues and debates that impact education. In a course where process is extremely important, participants are assessed on what they can do with content and process knowledge through preparing lesson plans, presenting lessons in a simulated classroom environment, and developing a portfolio and journal. Lesson plans demonstrate participant understanding of inquiry, using models, deductive and inductive approaches, links between communication skills and content knowledge, and effective use of technology, including the Internet. For each topic, the mixture of demonstration, experimentation, inquiry, and lecture models are explored through investigation, discovery, and analysis

Adalimumab dose tapering in patients with rheumatoid arthritis who are in long-standing clinical remission: results of the phase IV PREDICTRA study

Objective: To investigate the association between baseline disease activity and the occurrence of flares after adalimumab tapering or withdrawal in patients with rheumatoid arthritis (RA) in sustained remission. Methods: The PREDICTRA phase IV, randomised, double-blind (DB) study (ImPact of Residual Inflammation Detected via Imaging TEchniques, Drug Levels, and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Patients) enrolled patients with RA receiving adalimumab 40 mg every other week who were in sustained remission ≥6 months. After a 4-week, open-label lead-in (OL-LI) period, patients were randomised 5:1 to DB adalimumab taper (every 3 weeks) or withdrawal (placebo) for 36 weeks. The primary endpoint was the association between DB baseline hand and wrist MRI-detected inflammation with flare occurrence. Results: Of 146 patients treated during the OL-LI period, 122 were randomised to taper (n=102) or withdrawal (n=20) arms. Patients had a mean 12.9 years of active disease and had received adalimumab for a mean of 5.4 years (mean 2.2 years in sustained remission). Overall, 37 (36%) and 9 (45%) patients experienced a flare in the taper and withdrawal arms, respectively (time to flare, 18.0 and 13.3 weeks). None of the DB baseline disease characteristics or adalimumab concentration was associated with flare occurrence after adalimumab tapering. Approximately half of the patients who flared regained clinical remission after 16 weeks of open-label rescue adalimumab. The safety profile was consistent with previous studies. Conclusions: Approximately one-third of patients who tapered adalimumab versus half who withdrew adalimumab experienced a flare within 36 weeks. Time to flare was numerically longer in the taper versus withdrawal arm. Baseline MRI inflammation was not associated with flare occurrence. Trial registration number: NCT02198651, EudraCT 2014-001114-26

The Globin Gene Repertoire of Lampreys: Convergent Evolution of Hemoglobin and Myoglobin in Jawed and Jawless Vertebrates

Agnathans (jawless vertebrates) occupy a key phylogenetic position for illuminating the evolution of vertebrate anatomy and physiology. Evaluation of the agnathan globin gene repertoire can thus aid efforts to reconstruct the origin and evolution of the globin genes of vertebrates, a superfamily that includes the well-known model proteins hemoglobin and myoglobin. Here, we report a comprehensive analysis of the genome of the sea lamprey (Petromyzon marinus) which revealed 23 intact globin genes and two hemoglobin pseudogenes. Analyses of the genome of the Arctic lamprey (Lethenteron camtschaticum) identified 18 full length and five partial globin gene sequences. The majority of the globin genes in both lamprey species correspond to the known agnathan hemoglobins. Both genomes harbor two copies of globin X, an ancient globin gene that has a broad phylogenetic distribution in the animal kingdom. Surprisingly, we found no evidence for an ortholog of neuroglobin in the lamprey genomes. Expression and phylogenetic analyses identified an ortholog of cytoglobin in the lampreys; in fact, our results indicate that cytoglobin is the only orthologous vertebrate-specific globin that has been retained in both gnathostomes and agnathans. Notably, we also found two globins that are highly expressed in the heart of P. marinus, thus representing functional myoglobins. Both genes have orthologs in L. camtschaticum. Phylogenetic analyses indicate that these heart-expressed globins are not orthologous to the myoglobins of jawed vertebrates (Gnathostomata), but originated independently within the agnathans. The agnathan myoglobin and hemoglobin proteins form a monophyletic group to the exclusion of functionally analogous myoglobins and hemoglobins of gnathostomes, indicating that specialized respiratory proteins for O2 transport in the blood and O2 storage in the striated muscles evolved independently in both lineages. This dual convergence of O2-transport and O2-storage proteins in agnathans and gnathostomes involved the convergent co-option of different precursor proteins in the ancestral globin repertoire of vertebrates

Multi-episodic remagnetization related to deformation in the Pyrenean Internal Sierras

The Internal Sierras (IS) in the southern margin of the Western and Central Axial Zone (Southern Pyrenees) are affected by a syn-orogenic remagnetization that provides information to reconstruct deformation geometries at the time of acquisition of magnetization. Furthermore, the IS structure changes strike along its structural trend, from ∼N120 to 130°E in the western and eastern margins to ∼N070–090°E in the central part. Palaeomagnetic techniques have been used to (i) accurately define the timing of remagnetization with regard to deformation and (ii) determine if the along-strike trend variation in the IS was induced by deformation and thrust emplacement during the Pyrenean compression or, on the contrary, was the result of a primary orientation controlled by structures inherited from pre-orogenic times. From 23 new palaeomagnetic sites, collected in Upper Cretaceous marls and marly limestones, two meaningful and stable palaeomagnetic components were resolved, principally carried by magnetite: (1) a lower-temperature component (B) that unblocks between 200 °C and 325–400 °C and (2) a higher-temperature component (C) that has been successfully isolated by means of combined thermal (up to 400 °C) and AF demagnetization (generally up to 50–100 mT). The B component is a late remagnetization that post-dates folding and emplacement of basement thrust sheets in the IS (mainly the Gavarnie thrust). It supports small but statistically significant clockwise rotations in the western part of the IS (from +18 to +26°). These rotations can be attributed to the westwards shortening decrease in the thrust system below the Gavarnie unit that results from its along-strike structural change, with a higher number of basement thrusts to the east. The C component has been interpreted as an early remagnetization, based on the results of conglomerate and fold tests. This component predates basement thrusting and is diachronous across the study area: reverse and normal polarities dominate in the eastern and western margins of the IS, respectively. New and previous palaeomagnetic data point out that curvature in the IS is probably a primary feature and the along-strike change in their trend could be interpreted as the result of basement geometrical features inherited from Variscan, Late Variscan or Mesozoic times. A complex, multi-episodic remagnetization probably related to burial and deformation processes occurred during Eocene times

The impact of COVID-19-related living restrictions on eating behaviours in children and adolescents: a systematic review

The COVID-19 pandemic prompted the imposition of physical and social distancing measures worldwide. Emerging data suggest that younger age groups may be particularly vulnerable to the adverse mental health impacts of the pandemic. Since the start of the COVID-19 pandemic, there has been an unprecedented increase in demand for child and adolescent eating disorder services. The aim of this review was to systematically review and appraise the current literature on the impact of COVID-19-related living restrictions on the eating behaviours of children and adolescents. Searches of eight electronic databases were conducted in March 2021 and December 2021 for published and grey literature on eating behaviours of population samples of children and adolescents (aged 18 months to 18 years old) who were exposed to COVID-19-related living restrictions. Of 3165 retrieved references, sixteen studies were included in this review, comprising data from 125, 286 participants. There was a pattern towards healthier eating behaviours among children and adolescents during the COVID-19 lockdown. However, young people from lower socioeconomic groups showed a tendency towards more unhealthy eating behaviours, and there was an association between mood difficulties and greater changes in eating; this suggests that such groups may be more vulnerable to the adverse health consequences of lockdowns

FlexRiLoG -- A SageMath Package for Motions of Graphs

In this paper we present the SageMath package FlexRiLoG (short for flexible and rigid labelings of graphs). Based on recent results the software generates motions of graphs using special edge colorings. The package computes and illustrates the colorings and the motions. We present the structure and usage of the package

Self-Stabilizing Byzantine Resilient Topology Discovery and Message Delivery

Traditional Byzantine resilient algorithms use $2f + 1$ vertex disjoint paths to ensure message delivery in the presence of up to f Byzantine nodes. The question of how these paths are identified is related to the fundamental problem of topology discovery. Distributed algorithms for topology discovery cope with a never ending task, dealing with frequent changes in the network topology and unpredictable transient faults. Therefore, algorithms for topology discovery should be self-stabilizing to ensure convergence of the topology information following any such unpredictable sequence of events. We present the first such algorithm that can cope with Byzantine nodes. Starting in an arbitrary global state, and in the presence of f Byzantine nodes, each node is eventually aware of all the other non-Byzantine nodes and their connecting communication links. Using the topology information, nodes can, for example, route messages across the network and deliver messages from one end user to another. We present the first deterministic, cryptographic-assumptions-free, self-stabilizing, Byzantine-resilient algorithms for network topology discovery and end-to-end message delivery. We also consider the task of r-neighborhood discovery for the case in which $r$ and the degree of nodes are bounded by constants. The use of r-neighborhood discovery facilitates polynomial time, communication and space solutions for the above tasks. The obtained algorithms can be used to authenticate parties, in particular during the establishment of private secrets, thus forming public key schemes that are resistant to man-in-the-middle attacks of the compromised Byzantine nodes. A polynomial and efficient end-to-end algorithm that is based on the established private secrets can be employed in between periodical re-establishments of the secrets

Reliability of team-based self-monitoring in critical events: A pilot study

Background: Teamwork is a critical component during critical events. Assessment is mandatory for remediation and to target training programmes for observed performance gaps. Methods: The primary purpose was to test the feasibility of team-based self-monitoring of crisis resource management with a validated teamwork assessment tool. A secondary purpose was to assess item-specific reliability and content validity in order to develop a modified context-optimised assessment tool.We conducted a prospective, single-centre study to assess team-based self-monitoring of teamwork after in-situ inter-professional simulated critical events by comparison with an assessment by observers. The Mayo High Performance Teamwork Scale (MHPTS) was used as the assessment tool with evaluation of internal consistency, item-specific consensus estimates for agreement between participating teams and observers, and content validity. Results: 105 participants and 58 observers completed the MHPTS after a total of 16 simulated critical events over 8 months. Summative internal consistency of the MHPTS calculated as Cronbachs alpha was acceptable with 0.712 for observers and 0.710 for participants. Overall consensus estimates for dichotomous data (agreement/non-agreement) was 0.62 (Cohens kappa; IQ-range 0.31-0.87). 6/16 items had excellent (kappa > 0.8) and 3/16 good reliability (kappa > 0.6). Short questions concerning easy to observe behaviours were more likely to be reliable. The MHPTS was modified using a threshold for good reliability of kappa > 0.6. The result is a 9 item self-assessment tool (TeamMonitor) with a calculated median kappa of 0.86 (IQ-range: 0.67-1.0) and good content validity.Conclusions: Team-based self-monitoring with the MHPTS to assess team performance during simulated critical events is feasible. A context-based modification of the tool is achievable with good internal consistency and content validity. Further studies are needed to investigate if team-based self-monitoring may be used as part of a programme of assessment to target training programmes for observed performance gaps. © 2013 Stocker et al.; licensee BioMed Central Ltd